Quantification and reduction of cross-vendor variation in multicenter DWI MR imaging: results of the Cancer Core Europe imaging task force

Oliver Lukas Sedlaczek, Jens Kleesiek, Ferdia A. Gallagher, Jacob Murray, Sebastian Prinz, Raquel Perez-Lopez, Evia Sala, Caroline Caramella, Sebastian Diffetock, Nathalie Lassau, Andrew N. Priest, Chikako Suzuki, Roberto Vargas, Tommaso Giandini, Marta Vaiani, Antonella Messina, Lennart K. Blomqvist, Regina G. H. Beets-Tan, Petra Oberrauch, Heinz-Peter Schlemmer, Michael Bach, for the CCE – Imaging Task Force
June, 2022
Cite DOI URL

Abstract

In the Cancer Core Europe Consortium (CCE), standardized biomarkers are required for therapy monitoring oncologic multicenter clinical trials. Multiparametric functional MRI and particularly diffusion-weighted MRI offer evident advantages for noninvasive characterization of tumor viability compared to CT and RECIST. A quantification of the inter- and intraindividual variation occurring in this setting using different hardware is missing. In this study, the MRI protocol including DWI was standardized and the residual variability of measurement parameters quantified.

Type
Journal article
Publication
European Radiology
Diffusion-weighted MRI Magnetic resonance imaging Multicenter oncologic studies Measurement Variability Radiomics
Jens Kleesiek
Jens Kleesiek
Professor of Translational Image-guided Oncology
Jacob Murray
Jacob Murray
MD Candidate